Testimonial - Lightcore Technologies

Testimonial – Pr. Brian SPRING

Dylan Septier — Mon, 15 Jun 2026 12:03:43 +0000

Name: Brian Spring
University / Institution: Northeastern University
Department / Research Group: Department of Physics, Spring Laboratory
Position / Title: Associate Professor of Physics
Research Area / Specialization: Biomedical Optics, Multiphoton Microscopy, Optical Fiber Endoscopy, Precision Photomedicine

1. Please briefly describe your research focus and current projects.

Our research focuses on the development of advanced optical imaging and photomedicine technologies for cancer detection, image-guided therapy, and the study of tumor–immune interactions. Current projects include the development of fiber-scanning multiphoton microendoscopes, hyperspectral microendoscopy systems, and ultrafast laser-based imaging platforms for preclinical and translational biomedical applications.

2. What research needs or challenge were you aiming to address when looking for a
solution ?

We required an optical fiber capable of delivering ultrashort femtosecond laser pulses through a flexible endoscopic platform while minimizing nonlinear distortion and preserving pulse quality. Conventional solid-core fibers often introduce significant dispersion and nonlinear effects that degrade pulse duration and limit imaging performance in multiphoton applications.

3. What factors influenced your decision to select our system ?

Our experience has been very positive. The fibers are mechanically flexible, well constructed, and straightforward to integrate into our experimental systems. The double-clad antiresonant hollow-core fiber has enabled reliable delivery of ultrashort laser pulses through our fiber-scanning multiphoton microendoscope while maintaining excellent optical performance.

4. How has your experience been using our system in your research work ?

Our experience with the Lightcore Technologies BondXplorer system in our research has been extremely positive. This system has significantly improved the quality and efficiency of our histopathological analyses through label-free, high-resolution molecular imaging with remarkable ease of use. Its multimodal capabilities have allowed us to obtain rich structural and biochemical information from tissue samples, while reducing preparation time and preserving sample integrity. We were particularly impressed by the microscope’s ergonomics, which integrate seamlessly into our workflow and enable rapid acquisition of highly reproducible data. The advanced imaging performance of the BondXplorer has opened new avenues for more in-depth tissue characterization and has significantly enhanced the scientific value and impact of our research projects.

5. Have our system contributed to any improvements in your workflow, experiments,
efficiency, or research outcomes ?

Yes. The fiber has enabled us to deliver sub-50 femtosecond laser pulses to the sample plane through the endoscope, supporting high-efficiency multiphoton excitation and improved imaging performance. The combination of low pulse distortion and practical mechanical handling has simplified system development and helped advance our research objectives.

6. Are there any specific features or aspects you particularly value ?

We particularly value the low nonlinearity of the hollow-core design, the ability to preserve ultrashort pulse durations, the double-clad architecture for endoscopic imaging applications, and the excellent mechanical flexibility. The overall build quality and consistency of the fibers have also been important advantages.

7. Would you recommend our system to other researchers or institutions ? Why ?

Yes. I would recommend LightCore’s antiresonant hollow-core fibers to researchers developing ultrafast laser delivery systems, multiphoton imaging platforms, and fiber-based endoscopes. The fibers provide an effective solution for preserving ultrashort pulse quality while offering the mechanical robustness and flexibility needed for practical biomedical and scientific applications, with potential for clinical translation.

The post Testimonial – Pr. Brian SPRING first appeared on Lightcore Technologies.

Testimonial – Pr. Marc Van Zandvoort

Dylan Septier — Wed, 03 Jun 2026 11:30:17 +0000

Name: Marc Van Zandvoort
University / Institution: Maastricht University
Department / Research Group: Expert Group “Advanced Optical Microscopy”
Position / Title: Chair Professor
Research Area / Specialization: BioMedical and Plants

1. Please briefly describe your research focus and current projects.

My focus is on incorporating advanced techniques like multiphoton microscopy in biomedical and plant research, specifically basic research, but also in clinic. Mainly cardiovascular (athero), oncology and development (pre-eclampsia), and brain (epilepsy). Furthermore, plant (wheat) crop imaging

2. What research needs or challenge were you aiming to address when looking for a
solution ?

Bringing multiphoton to the clinic by making the set-up mobile and allowing local (e.g., surgery room) measurements at complex locations

3. What factors influenced your decision to select our system ?

Uniqueness

4. How has your experience been using our system in your research work ?

Very good, although we just started. Callibration was easy, good interaction with the company

5. Have our system contributed to any improvements in your workflow, experiments,
efficiency, or research outcomes ?

Not yet, since we just started. But quite sure it will. Both in biomedical research and plant imaging (in field crop)

6. Are there any specific features or aspects you particularly value ?

Mobility, ease of use, flexibility, quality of imaging, interaction with company

7. Would you recommend our system to other researchers or institutions ? Why ?

Definitely, because of the above-mentioned properties

The post Testimonial – Pr. Marc Van Zandvoort first appeared on Lightcore Technologies.

Testimonial – Dr. Tobias Meyer-Zedler

Dylan Septier — Wed, 03 Jun 2026 11:29:27 +0000

Name: Dr. Tobias Meyer-Zedler
University / Institution: Leibniz Institute of Photonic Technology
Department / Research Group: Molecular imaging
Position / Title: Research group head
Research Area / Specialization: multimodal nonlinear and coherent Raman microscopy and endoscopy

1. Please briefly describe your research focus and current projects.

My current research focuses on multimodal nonlinear microscopy and endoscopy, with applications in the detection of diseases such as cancer and infections, as well as in drug delivery monitoring and characterization.
A major part of my work is dedicated to the development and translation of advanced photonic imaging technologies for biomedical and clinical applications.
An important collaborative project is the Leibniz Center for Photonics in Infection Research (LPI), which aims to advance photonic solutions for rapid diagnostics and infection research.

2. What research needs or challenge were you aiming to address when looking for a
solution ?

We aimed to address the need for sensitive, label-free, and minimally invasive imaging techniques that enable early detection of diseases such as cancer and infections.
A major challenge was the translation of advanced multimodal nonlinear imaging methods from the laboratory into clinically relevant applications, including endoscopic systems for real-time diagnostics and monitoring of drug delivery processes.

3. What factors influenced your decision to select our system ?

We selected your products because they are, to our knowledge, the only commercially available double-clad hollow-core fibers that enable broadband laser delivery while preserving peak intensity and minimizing additional dispersion.
These properties are highly important for coherent Raman endoscopy, where efficient ultrashort pulse delivery and signal integrity are critical. In addition, the capability to collect the generated signal through the same fiber provides a highly attractive and practical solution for compact endoscopic implementations.

4. How has your experience been using our system in your research work ?

Our experience with the products has been very positive overall, particularly regarding broadband ultrafast pulse delivery and the integration of excitation and signal collection within the same fiber architecture. These features are highly valuable for coherent Raman endoscopy applications.
One remaining challenge is that the optical losses are still higher than desired for some applications, especially where maximum transmission efficiency and signal sensitivity are critical. Nevertheless, the fiber design offers significant advantages compared to currently available alternatives.

5. Have our system contributed to any improvements in your workflow, experiments,
efficiency, or research outcomes ?

Yes, the products have contributed to improvements in both experimental implementation and system integration. The fiber design simplifies the delivery of ultrafast broadband laser pulses and enables signal collection through the same optical path, which is highly beneficial for coherent Raman endoscopy setups. The part has been accelerating our translational research activities.

6. Are there any specific features or aspects you particularly value ?

We particularly value the combination of broadband ultrafast pulse delivery with low nonlinear distortion, as well as the double-clad hollow-core fiber design that enables simultaneous excitation and signal collection. The fiber facilitates translation of coherent Raman imaging techniques toward practical biomedical and clinical applications.

7. Would you recommend our system to other researchers or institutions ? Why ?

The products can be of considerable interest to researchers and institutions working in the fields of nonlinear microscopy, coherent Raman imaging, and biomedical endoscopy.
The products provide unique capabilities for broadband ultrafast laser delivery and combined signal collection, which are highly relevant for advanced photonic imaging applications. In particular, the availability of specialized fiber designs and integrated endoscopic solutions makes them attractive for both fundamental research and translational biomedical developments.

The post Testimonial – Dr. Tobias Meyer-Zedler first appeared on Lightcore Technologies.

Testimonial – Dr. Luca Ravotto

Dylan Septier — Wed, 03 Jun 2026 11:28:31 +0000

Name: Luca Ravotto
University / Institution: University of Zurich
Department / Research Group: Experimental Imaging and Bioenergetics – Dept. Pharmacology and Toxicology
Position / Title: Senior Scientist
Research Area / Specialization: Multiphoton Microscopy

1. Please briefly describe your research focus and current projects.

We work on fluorescent imaging in the mouse brain, to study metabolism, neurotransmission and hemodynamics. My role in particular is focused on the implementation of optical techniques (with a focus on Fluorescence Lifetime Imaging) and data analysis tools.

2. What research needs or challenge were you aiming to address when looking for a
solution ?

As part of our studies, we were implementing a mini2P microscope for brain imaging of freely behaving mice.

3. What factors influenced your decision to select our system ?

The photonics crystal fiber from LightCore offered a unique combination of low dispersion across a broad wavelength range.

4. How has your experience been using our system in your research work ?

The fiber is of high quality and worked with no problem. The custom-made collimation adapter for the mini2P was also robust and well functional. The coupling box offered an easy alignment experience.

5. Have our system contributed to any improvements in your workflow, experiments,
efficiency, or research outcomes ?

Significant simplification of alignment and flexibility in the choice of the excitation wavelength.

6. Are there any specific features or aspects you particularly value ?

The broad wavelength range in which the fiber can be operated.

7. Would you recommend our system to other researchers or institutions ? Why ?

Definitely, and in fact I already have. For the transport of femtosecond pulses for multiphoton excitation the fiber from LightCore is the only one I know of to offer high transmittance and very low dispersion across a very wide wavelength range.

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