Lightcore Technologies

Testimonial – Pr. Brian SPRING

Dylan Septier — Mon, 15 Jun 2026 12:03:43 +0000

Name: Brian Spring
University / Institution: Northeastern University
Department / Research Group: Department of Physics, Spring Laboratory
Position / Title: Associate Professor of Physics
Research Area / Specialization: Biomedical Optics, Multiphoton Microscopy, Optical Fiber Endoscopy, Precision Photomedicine

1. Please briefly describe your research focus and current projects.

Our research focuses on the development of advanced optical imaging and photomedicine technologies for cancer detection, image-guided therapy, and the study of tumor–immune interactions. Current projects include the development of fiber-scanning multiphoton microendoscopes, hyperspectral microendoscopy systems, and ultrafast laser-based imaging platforms for preclinical and translational biomedical applications.

2. What research needs or challenge were you aiming to address when looking for a
solution ?

We required an optical fiber capable of delivering ultrashort femtosecond laser pulses through a flexible endoscopic platform while minimizing nonlinear distortion and preserving pulse quality. Conventional solid-core fibers often introduce significant dispersion and nonlinear effects that degrade pulse duration and limit imaging performance in multiphoton applications.

3. What factors influenced your decision to select our system ?

Our experience has been very positive. The fibers are mechanically flexible, well constructed, and straightforward to integrate into our experimental systems. The double-clad antiresonant hollow-core fiber has enabled reliable delivery of ultrashort laser pulses through our fiber-scanning multiphoton microendoscope while maintaining excellent optical performance.

4. How has your experience been using our system in your research work ?

Our experience with the Lightcore Technologies BondXplorer system in our research has been extremely positive. This system has significantly improved the quality and efficiency of our histopathological analyses through label-free, high-resolution molecular imaging with remarkable ease of use. Its multimodal capabilities have allowed us to obtain rich structural and biochemical information from tissue samples, while reducing preparation time and preserving sample integrity. We were particularly impressed by the microscope’s ergonomics, which integrate seamlessly into our workflow and enable rapid acquisition of highly reproducible data. The advanced imaging performance of the BondXplorer has opened new avenues for more in-depth tissue characterization and has significantly enhanced the scientific value and impact of our research projects.

5. Have our system contributed to any improvements in your workflow, experiments,
efficiency, or research outcomes ?

Yes. The fiber has enabled us to deliver sub-50 femtosecond laser pulses to the sample plane through the endoscope, supporting high-efficiency multiphoton excitation and improved imaging performance. The combination of low pulse distortion and practical mechanical handling has simplified system development and helped advance our research objectives.

6. Are there any specific features or aspects you particularly value ?

We particularly value the low nonlinearity of the hollow-core design, the ability to preserve ultrashort pulse durations, the double-clad architecture for endoscopic imaging applications, and the excellent mechanical flexibility. The overall build quality and consistency of the fibers have also been important advantages.

7. Would you recommend our system to other researchers or institutions ? Why ?

Yes. I would recommend LightCore’s antiresonant hollow-core fibers to researchers developing ultrafast laser delivery systems, multiphoton imaging platforms, and fiber-based endoscopes. The fibers provide an effective solution for preserving ultrashort pulse quality while offering the mechanical robustness and flexibility needed for practical biomedical and scientific applications, with potential for clinical translation.

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Testimonial – Dr. Anthony SEBILLOT

Dylan Septier — Wed, 03 Jun 2026 11:31:00 +0000

Name: Anthony SEBILLOT
University / Institution: Université de Rennes
Department / Research Group: Biosit (UMS/UAR CNRS 3480 – INSERM 018)
Position / Title: Research Engineer Inserm, Manager at H2P2 Core Facility (Histo
pathology High precision).
Research Area / Specialization: Histopathology

1. Please briefly describe your research focus and current projects.

H2P2 facility is a multidisciplinary core facility dedicated to advanced tissue analysis and high-resolution biological imaging. It provides a comprehensive environment for histological processing, histopathological evaluation, and phenotypic characterization of biological samples in both basic and translational research contexts. The platform integrates state-of-the-art instrumentation and expertise in tissue preparation, microscopy, and digital imaging, enabling high-quality morphological and molecular investigations.
The H2P2 facility performs histology work on animal and plant tissue. We bring our technical and technological skills in the various fields of histopathology.
We carry out tissue fixation, paraffin impregnation, thin sections with a microtome and cryostat, histology stainings (hematoxylin-eosin-saffron [HES], Sirius Red, Periodic acid-Schiff [PAS], Fontana-Masson, Oil red O staining, and many others stainings suitable for specific requests). An immunohistochemistry slide stainers (Ventana Discovery), designed specifically for research is available. This equipment can be used to improve the optimisation and reproducibility of immunohistochemical labelling, on a carrousel of 30 slides, each treated independently (choice of antigen unmasking buffer, temperature, and incubation time). This machine allows us to respond rapidly to the demands of users. This equipment has load rate of above 95%.
We also have extensive expertise in laser capture microdissection and we propose tissue studies by immunohistochemistry and fluorescent detection, in situ hybridisation, organotypic cultures (vibratome). We have expertise in immunolabelling (more than 1500 antibodies in our catalogue) as well as immunohistochemical staining: simplex ; multiplex staining, a technique that can highlight up to 6 different proteins per slide, using fluorescent or chromogenic markers ; hyperplex: actually more than 20 biomarkers to progress to 30 biomarkers in the next months).
We are developing Raman microspectroscopy imaging (Spontaneous/Stimulated Raman (SRS) on biological samples. We produce Tissue Microarrays (TMA) that can hold hundreds of tissues on a single microscope slide and we perform clarification (CUBIC/RapiClear) and marking of samples such as organoids, sections and entire organs.
H2P2 also performed production virtual slides (brightfield and fluorescence imaging) and 2D image analysis (QuPath) and chemometrics. We visualise our slides using an epifluorescence microscope but also virtual slides from a Hamamatsu scanner with fluorescence. A confocal scanner, which is able to scan in depth, up to 300μm, with up to 7 different dyes. This scanner works also on brightfield mode. Its great interest is the ability to produce high resolution 3D images.
The equipment that equips the platform has been chosen to meet the needs of research laboratories. They offer great programming flexibility while providing reproducibility through automation.

2. What research needs or challenge were you aiming to address when looking for a
solution ?

We are constantly striving for improvement and progress. The H2P2 platform aim is to be able to continue to offer the cutting-edge technologies to research teams. Some devices/techniques are only available by the H2P2 team.

3. What factors influenced your decision to select our system ?

The choice of Lightcore Technologies’ BondXplorer for histopathological analysis was based on a combination of scientific and operational factors. The main criteria are likely the following:
Label-free tissue characterization
The BondXplorer enables molecular and structural imaging without the need for dyes or fluorescent markers. In histopathology, this feature is invaluable as it preserves tissue integrity, reduces preparation variability, and can accelerate the workflow compared to conventional staining methods.
High chemical specificity
H2P2 facility uses nonlinear optical and Raman imaging approaches that provide biochemical information directly from the tissue. This allows for the differentiation of tissue types, tumor margins, fibrosis, lipid distribution, and cellular architecture with molecular contrast superior to that of standard brightfield microscopy.
Reduced sample preparation time
Traditional histopathology often requires fixation, sectioning, staining, and multiple processing steps. A label-free optical workflow can shorten turnaround time and facilitate faster decision-making in research or translational medicine. Multimodal imaging capability: BondXplorer combines multiple imaging modalities within a single platform. For histopathological analysis, this enables the simultaneous acquisition of structural and molecular information, thus improving diagnostic reliability and tissue interpretation.
Multimodal imaging capability
BondXplorer combines multiple imaging modalities within a single platform. For histopathological analysis, this enables the simultaneous acquisition of structural and molecular information, thus improving the reliability of tissue analysis.
Preservation of native tissue state
Since chemical staining can alter biological samples, label-free imaging helps maintain the tissue closer to its native physiological condition. This is particularly important for research applications involving biomarker discovery.
Compatibility with digital pathology and AI workflows
Modern histopathology increasingly relies on quantitative image analysis and machine learning. The rich spectral and structural datasets generated by BondXplorer may support computational pathology and AI-assisted classification approaches.
Compact and user-friendly instrumentation
Lightcore emphasizes simplified deployment and reduced alignment complexity compared with traditional advanced optical systems. For a shared pathology or imaging facility, operational simplicity and lower maintenance requirements are major advantages.
Cost-efficiency over conventional high-end multimodal systems
The balance between imaging performance, versatility, size, and operating cost has made the BongXplorer attractive compared to larger or more specialized histopathology imaging platforms.

4. How has your experience been using our system in your research work ?

5. Have our system contributed to any improvements in your workflow, experiments,
efficiency, or research outcomes ?

The BondXplorer microscope has significantly improved our workflow, the efficiency of our experiments, and consequently, our research results. Its rapid, label-free imaging capabilities have significantly reduced sample preparation time and streamlined our histopathological analysis process, allowing us to analyze a larger number of samples with greater consistency and reliability. The high quality of the multimodal data generated by the system has improved the accuracy and depth of our tissue characterization, resulting in more robust findings. Furthermore, the platform’s intuitive interface and ease of use have facilitated training for our team and its daily operation. In summary, the BondXplorer has significantly increased our productivity, accelerated data acquisition and interpretation, and contributed to improved scientific quality across several ongoing research projects.

6. Are there any specific features or aspects you particularly value ?

We particularly value the exceptional label-free imaging capabilities of the BondXplorer microscope, which allow us to obtain highly detailed molecular and structural information while preserving the native state of tissue samples. The multimodal imaging approach is especially valuable, as it provides complementary biochemical and morphological insights within a single platform, greatly enhancing the depth of our analyses. We also highly appreciate the system’s ease of use, operational stability, and compact design, which make it well suited for routine use in a demanding research environment. In addition, the speed of image acquisition, the excellent reproducibility of results, and the overall quality of the generated data have been particularly impressive and have become major strengths in our research workflow.
The acquisition of the BondXplorer microscope represents a major strategic asset for the development of new collaborative projects and the strengthening of our innovation capabilities. This cutting-edge technology now enables us to respond much more competitively to national and European funding calls by proposing innovative approaches in histopathological imaging and label-free molecular analysis. The system also serves as a key driver for initiating and structuring multiple scientific and industrial collaborations with leading academic partners. Thanks to its advanced performance, versatility, and strong translational potential, the BondXplorer significantly enhances the attractiveness of our technological platform and opens new opportunities for multidisciplinary research projects with high scientific and applied impact.

7. Would you recommend our system to other researchers or institutions ? Why ?

Yes, I would highly recommend the BondXplorer system from Lightcore Technologies to other research institutions and laboratories. The system combines advanced label-free molecular imaging capabilities with excellent ease of use, and multimodal analysis performance, making it a highly valuable tool for histopathology and translational research. Its ability to generate high-quality structural and biochemical information while reducing sample preparation time has significantly improved our workflow efficiency, data reproducibility, and overall research productivity. In addition, the versatility and innovative nature of the microscope create strong opportunities for the development of collaborative projects, industrial partnerships, and competitive funding applications with leading academic institutions.
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Finally, the Lightcore Technologies support team demonstrates exceptional expertise, responsiveness, and customer service, significantly enhancing the BondXplorer system user experience. Always available to answer technical and scientific questions, they ensure rapid problem resolution and minimize disruption to ongoing experiments. Beyond troubleshooting, they offer valuable guidance on optimizing system performance, adapting imaging protocols, and improving data quality, which directly impacts research results. Their proactive approach, strong scientific understanding, and commitment to user success make them a reliable and trusted partner for our research activities. In short, the quality and responsiveness of Lightcore’s support are major assets that greatly contribute to the seamless integration and effective use of the technology within our research platform.

The post Testimonial – Dr. Anthony SEBILLOT first appeared on Lightcore Technologies.

Testimonial – Pr. Marc Van Zandvoort

Dylan Septier — Wed, 03 Jun 2026 11:30:17 +0000

Name: Marc Van Zandvoort
University / Institution: Maastricht University
Department / Research Group: Expert Group “Advanced Optical Microscopy”
Position / Title: Chair Professor
Research Area / Specialization: BioMedical and Plants

1. Please briefly describe your research focus and current projects.

My focus is on incorporating advanced techniques like multiphoton microscopy in biomedical and plant research, specifically basic research, but also in clinic. Mainly cardiovascular (athero), oncology and development (pre-eclampsia), and brain (epilepsy). Furthermore, plant (wheat) crop imaging

2. What research needs or challenge were you aiming to address when looking for a
solution ?

Bringing multiphoton to the clinic by making the set-up mobile and allowing local (e.g., surgery room) measurements at complex locations

3. What factors influenced your decision to select our system ?

Uniqueness

4. How has your experience been using our system in your research work ?

Very good, although we just started. Callibration was easy, good interaction with the company

5. Have our system contributed to any improvements in your workflow, experiments,
efficiency, or research outcomes ?

Not yet, since we just started. But quite sure it will. Both in biomedical research and plant imaging (in field crop)

6. Are there any specific features or aspects you particularly value ?

Mobility, ease of use, flexibility, quality of imaging, interaction with company

7. Would you recommend our system to other researchers or institutions ? Why ?

Definitely, because of the above-mentioned properties

The post Testimonial – Pr. Marc Van Zandvoort first appeared on Lightcore Technologies.

Testimonial – Dr. Tobias Meyer-Zedler

Dylan Septier — Wed, 03 Jun 2026 11:29:27 +0000

Name: Dr. Tobias Meyer-Zedler
University / Institution: Leibniz Institute of Photonic Technology
Department / Research Group: Molecular imaging
Position / Title: Research group head
Research Area / Specialization: multimodal nonlinear and coherent Raman microscopy and endoscopy

1. Please briefly describe your research focus and current projects.

My current research focuses on multimodal nonlinear microscopy and endoscopy, with applications in the detection of diseases such as cancer and infections, as well as in drug delivery monitoring and characterization.
A major part of my work is dedicated to the development and translation of advanced photonic imaging technologies for biomedical and clinical applications.
An important collaborative project is the Leibniz Center for Photonics in Infection Research (LPI), which aims to advance photonic solutions for rapid diagnostics and infection research.

2. What research needs or challenge were you aiming to address when looking for a
solution ?

We aimed to address the need for sensitive, label-free, and minimally invasive imaging techniques that enable early detection of diseases such as cancer and infections.
A major challenge was the translation of advanced multimodal nonlinear imaging methods from the laboratory into clinically relevant applications, including endoscopic systems for real-time diagnostics and monitoring of drug delivery processes.

3. What factors influenced your decision to select our system ?

We selected your products because they are, to our knowledge, the only commercially available double-clad hollow-core fibers that enable broadband laser delivery while preserving peak intensity and minimizing additional dispersion.
These properties are highly important for coherent Raman endoscopy, where efficient ultrashort pulse delivery and signal integrity are critical. In addition, the capability to collect the generated signal through the same fiber provides a highly attractive and practical solution for compact endoscopic implementations.

4. How has your experience been using our system in your research work ?

Our experience with the products has been very positive overall, particularly regarding broadband ultrafast pulse delivery and the integration of excitation and signal collection within the same fiber architecture. These features are highly valuable for coherent Raman endoscopy applications.
One remaining challenge is that the optical losses are still higher than desired for some applications, especially where maximum transmission efficiency and signal sensitivity are critical. Nevertheless, the fiber design offers significant advantages compared to currently available alternatives.

5. Have our system contributed to any improvements in your workflow, experiments,
efficiency, or research outcomes ?

Yes, the products have contributed to improvements in both experimental implementation and system integration. The fiber design simplifies the delivery of ultrafast broadband laser pulses and enables signal collection through the same optical path, which is highly beneficial for coherent Raman endoscopy setups. The part has been accelerating our translational research activities.

6. Are there any specific features or aspects you particularly value ?

We particularly value the combination of broadband ultrafast pulse delivery with low nonlinear distortion, as well as the double-clad hollow-core fiber design that enables simultaneous excitation and signal collection. The fiber facilitates translation of coherent Raman imaging techniques toward practical biomedical and clinical applications.

7. Would you recommend our system to other researchers or institutions ? Why ?

The products can be of considerable interest to researchers and institutions working in the fields of nonlinear microscopy, coherent Raman imaging, and biomedical endoscopy.
The products provide unique capabilities for broadband ultrafast laser delivery and combined signal collection, which are highly relevant for advanced photonic imaging applications. In particular, the availability of specialized fiber designs and integrated endoscopic solutions makes them attractive for both fundamental research and translational biomedical developments.

The post Testimonial – Dr. Tobias Meyer-Zedler first appeared on Lightcore Technologies.

Testimonial – Dr. Luca Ravotto

Dylan Septier — Wed, 03 Jun 2026 11:28:31 +0000

Name: Luca Ravotto
University / Institution: University of Zurich
Department / Research Group: Experimental Imaging and Bioenergetics – Dept. Pharmacology and Toxicology
Position / Title: Senior Scientist
Research Area / Specialization: Multiphoton Microscopy

1. Please briefly describe your research focus and current projects.

We work on fluorescent imaging in the mouse brain, to study metabolism, neurotransmission and hemodynamics. My role in particular is focused on the implementation of optical techniques (with a focus on Fluorescence Lifetime Imaging) and data analysis tools.

2. What research needs or challenge were you aiming to address when looking for a
solution ?

As part of our studies, we were implementing a mini2P microscope for brain imaging of freely behaving mice.

3. What factors influenced your decision to select our system ?

The photonics crystal fiber from LightCore offered a unique combination of low dispersion across a broad wavelength range.

4. How has your experience been using our system in your research work ?

The fiber is of high quality and worked with no problem. The custom-made collimation adapter for the mini2P was also robust and well functional. The coupling box offered an easy alignment experience.

5. Have our system contributed to any improvements in your workflow, experiments,
efficiency, or research outcomes ?

Significant simplification of alignment and flexibility in the choice of the excitation wavelength.

6. Are there any specific features or aspects you particularly value ?

The broad wavelength range in which the fiber can be operated.

7. Would you recommend our system to other researchers or institutions ? Why ?

Definitely, and in fact I already have. For the transport of femtosecond pulses for multiphoton excitation the fiber from LightCore is the only one I know of to offer high transmittance and very low dispersion across a very wide wavelength range.

The post Testimonial – Dr. Luca Ravotto first appeared on Lightcore Technologies.

Towards Spectrally Resolved Raman Endoscopy

Dylan Septier — Mon, 04 Nov 2024 14:13:24 +0000

Coherent Raman imaging has established itself as a powerful imaging technique in both research and clinical domains. Its ability to target specific molecular bonds enables highly specific imaging, opening up exciting possibilities in histological analysis and cellular imaging. At Lightcore Technology, we’re pushing these capabilities forward by bringing coherent anti-Stokes Raman scattering (CARS) imaging to a miniaturized, endoscopic format, tackling key technical challenges like four-wave mixing (FWM) background interference—a persistent obstacle in CARS imaging. Initial studies using femtosecond lasers confirmed the feasibility of this approach, but their short pulses, while delivering high peak power, limit spectral resolution. This hinders the discrimination of spectrally similar species within tissues.

Our research now focuses on integrating a compact, stable picosecond laser source for endoscopic CARS imaging. Partnering with Refined Laser Systems (RLS), we’ve incorporated the PICUS DUO EOM laser into our multiphoton endoscope, delivering pulses in the 1-4 ps range at 40 MHz. This pulse range provides an ideal compromise: ample peak power with enhanced spectral resolution. For this preliminary experiments, we set the wavenumber to 2850 cm⁻¹, targeting CH₂ bonds which are abundant in lipid-rich structures. Average powers were set at 50 mW for the pump (799 nm) and 90 mW for the Stokes (1034 nm), with images collected in epi-mode, ensuring a true endoscopic configuration.

In our initial trials with fixed tissue samples, the endoscope captured detailed structures across a range of tissues. Elastic fibers in the aorta revealed well-defined elastin patterns, while dry bone samples illustrated the lipid-rich matrix in sharp detail. Imaging brain tissue enabled visualization of neuronal structures, glial cells, and myelin sheaths, and imaging cardiac tissue captured organized cardiomyocytes and blood vessels. These results showcase the system’s resolution and detail, with clear differentiation across a range of tissue types.

As real-time imaging is essential for practical applications, we also demonstrated the endoscope’s ability to image fixed tissues in a live setting. We observed dense connective tissue, showing elastic fibers, and noted the absence of signal from collagen due to the focus on CH₂ bonds. Additionally, lymphatic structures and vessel interconnections typical of lymphatic anatomy were visible, reflecting the device’s capability to differentiate based on molecular content.

Lastly, we conducted in-vivo imaging on human abdominal skin using a custom pen endoscope, capturing structural detail approximately 150 µm beneath the skin surface. These images reveal a promising glimpse of cellular organizations within the dermis and possible sebaceous glands. The in-vivo capability of our endoscope opens a pathway for non-invasive, real-time examination of human tissues with molecular specificity, offering substantial potential for histological analysis, dermatological applications, and beyond.

The scale bar on all above images represents 60 µm.

These early findings demonstrate our progress in achieving spectrally resolved Raman imaging for endoscopy. Our technology promises a new approach to histological imaging, with implications across both research and clinical applications. We are excited to explore the future implications of this technology as we continue to refine and expand its capabilities.

The post Towards Spectrally Resolved Raman Endoscopy first appeared on Lightcore Technologies.

Stimulated Raman histology

Dylan Septier — Fri, 15 Dec 2023 08:02:58 +0000

A brief description of stimulated Raman imaging as a replacement for standard histology.

Rigneault_Photoniques-2023_Applications-medicales

The post Stimulated Raman histology first appeared on Lightcore Technologies.

BondXplorer™ multimodal microscope

Dylan Septier — Wed, 06 Dec 2023 16:01:34 +0000

New hope for rapid cancer diagnosis: the virtual histology revolution

Today, cancer diagnosis relies on complex techniques that are not always suited to emergency situations, such as surgery. At Lightcore Technologies, we’ve developed an innovative solution that could change all that.

Imagine a tool that enables doctors to see tissue structures at the cellular level, almost in real time. That’s what we’ve created with the BondXplorer™ microscope. Our technology, based on stimulated Raman imaging, can detect cancer in untreated human surgical specimens. It generates histological images that resemble those obtained with current techniques, but much more rapidly.

Our DC-SRS microscope uses this technology to follow the evolution of tumors in tissue. It produces images almost identical to those obtained with conventional techniques, but 100 times faster. This means that doctors could have access to crucial cancer information during surgery, without having to wait for test results.

We have already tested our technology on the brain and gastrointestinal system, and the results are promising. We believe it has the potential to revolutionize medical imaging in many fields.

If you would like to find out more about our revolutionary technology, please contact our PR team.

You can also see our BondXplorer technology in action on our YouTube channel:

The post BondXplorer™ multimodal microscope first appeared on Lightcore Technologies.

InSplorer™ flexible endoscope

Dylan Septier — Wed, 06 Dec 2023 15:59:37 +0000

Lightcore Technologies : A new hope for neurodegenerative diseases and cancer

Lightcore Technologies, an innovative company in the field of non-linear optical imaging, offers new hope for research into neurodegenerative diseases and cancer. Thanks to our InSplorer™ technology, we enable in-vivo brain imaging in freely-moving rodents, opening up new avenues for studying neuronal responses in their natural context.

Visualizing neurons in vivo: a world first

Lightcore Technologies InSplorer™ is the first commercial system to enable the visualization of neurons in-vivo. This major advance offers researchers an unprecedented window onto brain function, enabling them to study neuronal responses in their natural context. This could lead to revolutionary discoveries in the understanding and treatment of neurodegenerative diseases.

Concept validation by the Institut de la Méditerranée

The InSplorer™ concept has been validated by the Institut de Neurobiologie de la Méditerranée (INMED ), a renowned institution in the field of medical research. This validation underlines the potential of InSplorer™ technology and reinforces its credibility in the scientific community.

A revolution in cancer diagnosis

But the InSplorer™ is not limited to the study of neurodegenerative diseases. It also has the potential to revolutionize cancer diagnosis. Indeed, the InSplorer™ enables in-vivo diagnosis without the use of fluorescent markers, which could be a game-changer in the early detection of cancer.

In conclusion, Lightcore Technologies is at the forefront of innovation in medical imaging. Thanks to our InSplorer™ technology, they offer new hope for research into neurodegenerative diseases and cancer. For more information, please contact our team.

The post InSplorer™ flexible endoscope first appeared on Lightcore Technologies.

Revolutionizing nonlinear imaging : a new hope for neurodegenerative disorders and cancer

Dylan Septier — Wed, 06 Dec 2023 15:53:57 +0000

Lightcore Technologies is an innovative company that paves the way in the field of nonlinear optical imaging. Our cutting-edge technologies offer unprecedented potential for advancing research into neurodegenerative diseases, cancer and many other biomedical and scientific fields. Founded by photonics experts and backed by leading academic institutions, our mission is to transform medical research and patient care through our state-of-the-art imaging technologies.

Our products: BondXplorer Microscope and InSplorer Endoscope

Our products, such as the BondXplorer™ microscope and the InSplorer™ endoscope, offer photonics-based multimodal imaging and analysis solutions. These tools enable non-destructive, label-free investigation of pathophysiological processes in living samples at subcellular spatial resolution. They are not only innovative, but also compact, easy to use and affordable. Their unique design enables them to deliver high-quality images while minimizing the impact on the samples studied.

Our commitment: Innovation and collaboration

What sets Lightcore Technologies apart is our commitment to innovation through academic collaborations, numerous patents and technological breakthroughs. We are determined to push back the boundaries of what is possible in the field of brain imaging. We actively collaborate with researchers and clinicians around the world to develop and improve our technologies.

New hope for neurodegenerative diseases

Our InSplorer™ technology offers enormous potential for advancing research into neurodegenerative diseases. By enabling in-vivo brain imaging in freely-moving rodents, we are opening up new avenues for studying neuronal responses in their natural context. This could lead to revolutionary discoveries in the understanding and treatment of neurodegenerative diseases.

The InSplorer™ is the fruit of our commitment to innovation and is based on a unique patented technology. It offers high spatial resolution and enhanced sensitivity, making it ideal for studying neurodegenerative diseases. What’s more, its ease of use makes it ideally suited to the needs of researchers and clinicians alike.

A revolution in virtual histology: A new hope for rapid cancer diagnosis

Conventional hematoxylin, eosin and saffron (HES) histopathology, currently the “gold standard” for the pathological diagnosis of cancer, requires complex sample preparations that are not compatible with intraoperative situations where rapid decisions need to be made. Lightcore Technologies offers a solution to this challenge, providing pathologists with a near real-time technology that reveals tissue structures at the cellular level with HES histological quality. This tool could prove precious in guiding surgery, offering clear clinical benefit.

We have developed an innovative technology based on stimulated Raman imaging, capable of detecting cancer on untreated human surgical specimens. This technology, called Stimulated Raman Histology (SRH), generates images that mimic conventional HES histopathological staining, combining chemical and collagen information.

Our DC-SRS BondXplorer™ microscope uses this technology to detect tumor progression in tissue. It acquires images in the CH₂ (2850 cm-1) and CH₃ (2950 cm-1) bands, producing images virtually identical to those obtained in conventional histology, but in 100 times less time. This breakthrough paves the way for instantaneous label-free histology in an intraoperative setting.

Our technology is applicable to all organs. We have already successfully tested it on the brain and the gastrointestinal system, demonstrating its potential to revolutionize medical imaging in many fields.

These advances represent a revolution in histology and neurology, offering enormous potential for the rapid diagnosis of cancer. We invite you to come and see for yourself the revolutionary potential of our technologies. For further information, please contact our PR team.

For more information on the BondXplorer™ technology :

The post Revolutionizing nonlinear imaging : a new hope for neurodegenerative disorders and cancer first appeared on Lightcore Technologies.